Previous Preeclamptic Pregnancy and Chronic Hypertension Affects Current Preeclampsia at a Public Health Center in Bojonegoro, Indonesia
Abstract
Background: Preeclampsia is one of the leading causes of maternal mortality and occurs frequently in Indonesia. The high maternal mortality rate (MMR) reflects the low quality of health services during pregnancy, childbirth, and the postpartum period. This study aimed to analyze the risk factors associated with the incidence of preeclampsia among pregnant women at the Public Health Center in Sukosewu, Bojonegoro, Indonesia. Methods: This study used a cross-sectional design. The samples consisted of 120 pregnant women at the Public Health Center in Sukosewu, Bojonegoro District, Indonesia. Odds ratio and logistic regression tests were applied in this study. Results: Gravida (p = 0.046) and a history of chronic hypertension (p = 0.015) had a significant positive effect (p < 0.05) on the incidence of preeclampsia. Meanwhile, family history (p = 0.079), twin pregnancy (p = 0.999), gestational interval (p = 0.261), age (p = 0.132), BMI (p = 0.336), MAP (p = 0.997), history of hypertension during pregnancy (p = 0.260), and history of DM (p = 1.000) showed no significant effect on the incidence of preeclampsia. Conclusion: The incidence of preeclampsia among pregnant women at the Public Health Center in Sukosewu, Bojonegoro, Indonesia, was associated with the risk factors of previous preeclampsia and a history of chronic hypertension during pregnancy.
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Facca TA, Famá EAB, Mastroianni-Kirsztajn G, Sass N. Why Is Preeclampsia still an Important Cause of Maternal Mortality Worldwide? Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics. 2020;42(9):586-587. http://dx.doi.org/10.1055/s-0040-1714132
Chang KJ, Seow KM, Chen KH. Preeclampsia: Recent Advances in Predicting, Preventing, and Managing the Maternal and Fetal Life-Threatening Condition. International Journal of Environmental Research and Public Health. 2023;20(4):2994. http://dx.doi.org/10.3390/ijerph20042994
Akbar MIA, at all, 2018. The Massive Problem of Preeclampsia in Indonesia : In need of a designed national health care system. Pregnancy Hypertension. 2018;13(supplement 1):516. https://doi.org/10.1016/j.preghy.2018.08.051
Meazaw MW, Chojenta C, Muluneh MD, Loxton D. Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa. PLoS One. 2020;15(8):e0237600. http://dx.doi.org/10.1371/journal.pone.0237600
Ministry of Health of the Republic of Indonesia. Profil Kesehatan Indonesia Tahun 2023. Jakarta: Ministry of Health of the Republic of Indonesia; 2024.
Karrar SA, Martingano DJ, Hong PL. Preeclampsia. Treasure Island (FL): StatPearls Publishing; 2025. Available from: https://www.ncbi.nlm.nih.gov/sites/books/NBK570611/ (Accessed on 20 Dec 2025)
Turgut F, Awad AS, Abdel-Rahman EM. Acute Kidney Injury: Medical Causes and Pathogenesis. Journal of Clinical Medicine. 2023;12(1):375. http://dx.doi.org/10.3390/jcm12010375
Krishnan S, Suarez-Martinez AD, Bagher P, Gonzalez A, Liu R, Murfee WL, Mohandas R. Microvascular dysfunction and kidney disease: Challenges and opportunities? Microcirculation. 2021;28(3):e12661. http://dx.doi.org/10.1111/micc.12661
Vlasopoulou K, Synetos A, Ktenopoulos N, Katsaros O, Koliastasis L, Apostolos A, Drakopoulou M, Toutouzas K, Tsioufis C. Unmasking Left Ventricular Diastolic Dysfunction: Pathophysiology, Diagnosis, and Treatment Strategies. Medical Sciences. 2025;13(3):204. http://dx.doi.org/10.3390/medsci13030204
Fox R, Kitt J, Leeson P, Aye CYL, Lewandowski AJ. Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring. Journal of Clinical Medicine. 2019;8(10):1625. http://dx.doi.org/10.3390/jcm8101625
Alipova G, Ablakimova N, Tussupkaliyeva K, Bermagambetova S, Kosmuratova S, Karimsakova B, Gaiday A, Gaiday A, Dinets A, Tussupkaliyev A. Prevention of Pre-Eclampsia: Modern Strategies and the Role of Early Screening. Journal of Clinical Medicine. 2025;14(9):2970. http://dx.doi.org/10.3390/jcm14092970
Mustary M, Ansariadi, Syam A, Riskiyani S, Erika KA, Moedjiono AI, Lubis M. Preeclampsia: Etiology, Pathophysiology, Risk Factors, Impact and Prevention: A Narrative Review. Iranian Journal of Public Health. 2024;53(11):2392-2403. http://dx.doi.org/10.18502/ijph.v53i11.16941
Wu CT, Kuo CF, Lin CP, Huang YT, Chen SW, Wu HM, Chu PH. Association of family history with incidence and gestational hypertension outcomes of preeclampsia. International Journal of Cardiology Hypertension. 2021;9:100084. http://dx.doi.org/10.1016/j.ijchy.2021.100084
Khalil H, Gul S, Gul S, Habib M, Rashid U. Maternal Risk Factors and Outcome in Primigravida Patient with Preeclampsia and Eclampsia. Insight Journal of Health and Rehabilitation. 2025;3:472–477. http://dx.doi.org/10.71000/p5x9tr08
Aziz M, Kokiwar PR. Effectiveness of Counseling in Reducing Pregnancy-related Anxiety among Primigravida Women – A Quasi-experimental Study. Journal of Medical Sciences. 2025;45(5):183-188. http://dx.doi.org/10.4103/jmedsci.jmedsci_32_25
Angsar MD. Hipertensi dalam Kehamilan. Ilmu Kebidanan Sarwono Prawirohardjo. Jakarta: PT Bina Pustaka Sarwono Prawirohardjo; 2020.
Repley JM, Bates K, Mohiuddin SS. Physiology, Maternal Changes. [Updated 2023 Mar 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539766/ (Accessed on 20 Dec 2025)
Wang Y, Wu N, Shen H. A Review of Research Progress of Pregnancy with Twins with Preeclampsia. Risk Management and Healthcare Policy. 2021;14:1999-2010. http://dx.doi.org/10.2147/RMHP.S304040
Njoroge S, Kuriloff M, Mueller A, Lopes Perdigao J, Dhir R, Rana S. The Interval between births and the risk of recurrent preeclampsia among predominantly high risk women in urban tertiary care center. Pregnancy Hypertension. 2021;25:7-11. http://dx.doi.org/10.1016/j.preghy.2021.05.009
Shimizu H, Murakoshi T, Wakisaka S, Hamada Y, Shimizu Y, Iga K, Konno H, Sei K. Evaluating the risk factors for preeclampsia in subsequent pregnancies in patients with a history of preeclampsia: a single-institution retrospective study. Hypertension Research. 2025;48(4):1315–1320. https://doi.org/10.1038/s41440-025-02098-y
Flint B, Tadi P. Physiology, Aging. [Updated 2023 Jan 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK556106/ (Accessed on 20 Dec 2025)
Cífková R. Hypertension in Pregnancy: A Diagnostic and Therapeutic Overview. High Blood Pressure & Cardiovascular Prevention. 2023;30(4):289-303. http://dx.doi.org/10.1007/s40292-023-00582-5
Chang KJ, Seow KM, Chen KH. Preeclampsia: Recent Advances in Predicting, Preventing, and Managing the Maternal and Fetal Life-Threatening Condition. International Journal of Environmental Research and Public Health. 2023;20(4):2994. http://dx.doi.org/10.3390/ijerph20042994
Lin X, Li H. Obesity: Epidemiology, Pathophysiology, and Therapeutics. Frontiers in Endocrinology. 2021;12:706978. http://dx.doi.org/10.3389/fendo.2021.706978
Henning RJ. Obesity and obesity-induced inflammatory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity. American Journal of Cardiovascular Disease. 2021;11(4):504-529.
Stubert J, Reister F, Hartmann S, Janni W. The Risks Associated With Obesity in Pregnancy. Deutsches Ärzteblatt international. 2018;115(16):276-283. http://dx.doi.org/10.3238/arztebl.2018.0276
Zhu J, Zhang J, Syaza Razali N, Chern B, Tan KH. Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study. BMJ Open. 2021;11(8):e046161. http://dx.doi.org/10.1136/bmjopen-2020-046161
Oney T, Kaulhausen H. The value of the mean arterial blood pressure in the second trimester (MAP-2 value) as a predictor of pregnancy-induced hypertension and preeclampsia. A preliminary report. Clinical and Experimental Hypertension. Part B: Hypertension in Pregnancy. 1983;2(2):211-216. http://dx.doi.org/10.3109/10641958309006081
Nie X, Xu Z, Ren H. Analysis of risk factors of preeclampsia in pregnancy women with chronic hypertension and its impact pregnancy outcomes. BMC Pregnancy and Childbirth. 2024;24:307. https://doi.org/10.1186/s12884-024-06476-1
Khedagi AM, Bello NA. Hypertensive Disorders of Pregnancy. Cardiology Clinics. 2021;39(1):77-90. https://doi.org/10.1016/j.ccl.2020.09.005
Ramanlal R, Gupta V. Physiology, Vasodilation. [Updated 2023 Jan 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Available from: https://www.ncbi.nlm.nih.gov/sites/books/NBK557562/ (Accessed on 20 Dec 2025)
Do NC, Vestgaard M, Nørgaard SK, Damm P, Mathiesen ER, Ringholm L. Prediction and prevention of preeclampsia in women with preexisting diabetes: the role of home blood pressure, physical activity, and aspirin. Frontiers in Endocrinology. 2023;14:1166884. http://dx.doi.org/10.3389/fendo.2023.1166884
DOI: https://doi.org/10.33846/hd30403
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