Prevention of oral cross-infection by using povidone-iodine compared with other antiseptic agents for orally transmitted diseases: A Review

Alaa Saif Alqhtani, Abdulkarem Ali Ali Mohammed, Farouk Al-ghazaly, Ahmed Alareqi, Anis Irmawati

Abstract


The oral cavity is a high-risk infective site, and highly contagious diseases like viral infections are confirmed to be transmitted through it. Oral rinses are a very important and one of the most important objective methods and topical essential strategies to decrease the spread and transmission of contagious diseases. There is a gap in the literature regarding a comprehensive comparison between povidone-iodine and other formulations in terms of their effectiveness in preventing oral cross-infection and transmission of orally transmitted diseases. The authors performed a comprehensive literature review utilizing Google Scholar, PubMed, and Science Direct to review relevant studies over the previous years on the effectiveness of povidone-iodine in preventing oral cross-infection and transmission of orally transmitted diseases by using these keywords: oral transmitted diseases, povidone-iodine, cross-infection, and antiseptic.  This article includes a comprehensive overview of the existing knowledge regarding the effectiveness of povidone-iodine compared with other antiseptic agents in preventing oral cross-infection and transmission of orally transmitted diseases. Povidone-iodine has shown effective antiseptic properties in the oral cavity without disrupting its natural balance. It is a valuable anti-septic preventive oral-transmitted disease for patients and healthcare providers, and there is no evidence to show the side effects over a long time. Povidone-iodine can be safely used as antisepsis for the oral cavity for the prevention of orally transmitted diseases as personal prophylaxis, and it's the most effective mouth rinse for viral infection in the oral cavity due to its fast action.

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References


Dong J, Li W, Wang Q, Chen J, Zu Y, Zhou X, et al. Relationships Between Oral Microecosystem and Respiratory Diseases. Frontiers in Molecular Biosciences. 2022; 8. http://dx.doi.org/10.3389/fmolb.2021.718222

Sampaio-Maia B, Caldas IM, Pereira ML, Pérez-Mongiovi D, Araujo R. Chapter Four - The Oral Microbiome in Health and Its Implication in Oral and Systemic Diseases. In: Sariaslani S, Michael Gadd G, editors. Advances in Applied Microbiology. Academic Press; 2016 [cited 2024 May 17]. p. 171–210. https://doi.org/10.1016/bs.aambs.2016.08.002

Limeres Posse J, Diz Dios P, Scully C. Viral Diseases Transmissible by Kissing. In: Saliva Protection and Transmissible Diseases. 2017;53–92. http://dx.doi.org/10.1016/b978-0-12-813681-2.00004-4

Laheij AMGA, Kistler JO, Belibasakis GN, Välimaa H, de Soet JJ. Healthcare-associated viral and bacterial infections in dentistry. J Oral Microbiol. 2012;4. https://doi.org/10.3402/jom.v4i0.17659

Garrido L, Lyra P, Rodrigues J, Viana J, Mendes JJ, Barroso H. Revisiting Oral Antiseptics, Microorganism Targets and Effectiveness. Journal of Personalized Medicine. 2023;13(9):1332. http://dx.doi.org/10.3390/jpm13091332

Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental healthcare providers - PubMed. [cited 2024 May 17]. https://pubmed.ncbi.nlm.nih.gov/35994295/

Mateos-Moreno MV, Mira A, Ausina-Márquez V, Ferrer MD. Oral antiseptics against coronavirus: in-vitro and clinical evidence. Journal of Hospital Infection [Internet]. 2021 Jul;113:30–43. Available from: http://dx.doi.org/10.1016/j.jhin.2021.04.004

Lepelletier D, Maillard JY, Pozzetto B, Simon A. Povidone Iodine: Properties, Mechanisms of Action, and Role in Infection Control and Staphylococcus aureus Decolonization. Antimicrobial Agents and Chemotherapy. 2020;64(9). http://dx.doi.org/10.1128/aac.00682-20

Garcia-Sanchez A, Peña-Cardelles JF, Ordonez-Fernandez E, Montero-Alonso M, Kewalramani N, Salgado-Peralvo AO, et al. Povidone-Iodine as a Pre-Procedural Mouthwash to Reduce the Salivary Viral Load of SARS-CoV-2: A Systematic Review of Randomized Controlled Trials. Int J Environ Res Public Health. 2022;19(5):2877.

Daniell H, Nair SK, Esmaeili N, Wakade G, Shahid N, Ganesan PK, et al. Debulking SARS-CoV-2 in saliva using angiotensin-converting enzyme 2 in chewing gum to decrease oral virus transmission and infection. Molecular Therapy. 2022;30(5):1966–78.

Chopra A, Sivaraman K, Radhakrishnan R, Balakrishnan D, Narayana A. Can povidone-iodine gargle/mouth rinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update. Jpn Dent Sci Rev. 2021;57:39–45.

Ting M, Suzuki JB. SARS-CoV-2: Overview and Its Impact on Oral Health. Biomedicines. 2021;9(11):1690.

Bromberg N, Brizuela M. Preventing Cross-Infection in the Dental Office. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Sep 13]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK589669/

Hassandarvish P, Tiong V, Mohamed NA, Arumugam H, Ananthanarayanan A, Qasuri M, et al. In vitro virucidal activity of povidone-iodine gargle and mouthwash against SARS-CoV-2: implications for dental practice. Br Dent J. 2020;1–4.

Pelletier JS, Tessema B, Frank S, Westover JB, Brown SM, Capriotti JA. Efficacy of Povidone-Iodine Nasal and Oral Antiseptic Preparations Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2). Ear Nose Throat J. 2021;100(2_suppl):192S-196S.

Elzein R, Abdel-Sater F, Fakhreddine S, Hanna PA, Feghali R, Hamad H, et al. In vivo evaluation of the virucidal efficacy of chlorhexidine and povidone-iodine mouthwashes against salivary SARS-CoV-2. A randomized-controlled clinical trial. Journal of Evidence Based Dental Practice. 2021;21(3):101584. http://dx.doi.org/10.1016/j.jebdp.2021.101584

Ferrer MD, Barrueco ÁS, Martinez-Beneyto Y, Mateos-Moreno MV, Ausina-Márquez V, García-Vázquez E, et al. Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2. Sci Rep. 2021;11(1):24392.

Parhar HS, Tasche K, Brody RM, Weinstein GS, O’Malley BW, Shanti RM, et al. Topical preparations to reduce SARS‐CoV‐2 aerosolization in head and neck mucosal surgery. Head Neck. 2020;42(6):1268–72.

Ito Y, Ito T, Yamashiro K, Mineshiba F, Hirai K, Omori K, et al. Antimicrobial and antibiofilm effects of abietic acid on cariogenic Streptococcus mutans. Odontology. 2020;108(1):57–65.

Cuellar-Rufino S, Arroyo-Xochihua O, Salazar-Luna A, Arroyo-Helguera O. Iodine induces toxicity against Candida albicans and Candida glabrata through oxidative stress. Iran J Microbiol. 2022;14(2):260–7.

Khalifa C, Slim A, Maroua G, Sioud S, Hentati H, Selmi J. Herpes simplex virus infection: Management of primary oral lesions in children. Clin Case Rep. 2022;10(8):10.1002/ccr3.6127.

Capriotti K, Stewart KP, Pelletier JS, Capriotti J. A Novel Topical 2% Povidone-Iodine Solution for the Treatment of Common Warts: A Randomized, Double-Blind, Vehicle-Controlled Trial. Dermatol Ther (Heidelb). 2015;5(4):247–52.

Kramer A, Assadian O, Frank M, Bender C, Hinz P, Working Section for Clinical Antiseptic of the German Society for Hospital Hygiene. Prevention of post-operative infections after surgical treatment of bite wounds. GMS Krankenhhyg Interdiszip. 2010;5(2):Doc12.

Brookes ZLS, Bescos R, Belfield LA, Ali K, Roberts A. Current uses of chlorhexidine for management of oral disease: a narrative review. J Dent. 2020;103:103497.

Bednarek RS, Nassereddin A, Ramsey ML. Skin Antiseptics. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Sep 14]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK507853/

Merchel Piovesan Pereira B, Tagkopoulos I. Benzalkonium Chlorides: Uses, Regulatory Status, and Microbial Resistance. Appl Environ Microbiol. 2019;85(13):e00377-19.

Vergara-Buenaventura A, Castro-Ruiz C. Use of mouthwashes against COVID-19 in dentistry. British Journal of Oral and Maxillofacial Surgery. 2020;58(8):924–7.

Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Comparison of In Vitro Inactivation of SARS CoV-2 with Hydrogen Peroxide and Povidone-Iodine Oral Antiseptic Rinses. J Prosthodont. 2020;29(7):599–603.

Wilder-Smith A. What is the vaccine effect on reducing transmission in the context of the SARS-CoV-2 delta variant? The Lancet Infectious Diseases. 2022;22(2):152–3.

Verma SK, Dev Kumar B, Chaurasia A, Dubey D. Effectiveness of mouthwash against viruses: 2020 perspective. A systematic review. Minerva Dent Oral Sci. 2021;70(5):206–13.

Guenezan J, Garcia M, Strasters D, Jousselin C, Lévêque N, Frasca D, et al. Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2021;147(4):400–1.

Frank S, Capriotti J, Brown SM, Tessema B. Povidone-Iodine Use in Sinonasal and Oral Cavities: A Review of Safety in the COVID-19 Era. Ear Nose Throat J. 2020;99(9):586–93.

Fuse Y, Ogawa H, Tsukahara Y, Fuse Y, Ito Y, Shishiba Y, et al. Iodine Metabolism and Thyroid Function During the Perinatal Period: Maternal-Neonatal Correlation and Effects of Topical Povidone-Iodine Skin Disinfectants. Biol Trace Elem Res. 2023;201(6):2685–700.

Challacombe SJ, Kirk-Bayley J, Sunkaraneni VS, Combes J. Povidone iodine. Br Dent J. 2020;228(9):656–7.

Lim NA, Teng O, Ng CYH, Bao LXY, Tambyah PA, Quek AML, et al. Repurposing povidone-iodine to reduce the risk of SARS-CoV-2 infection and transmission: a narrative review. Annals of Medicine. 2022;54(1):1488–99. http://dx.doi.org/10.1080/07853890.2022.2076902




DOI: https://doi.org/10.33846/hd10506

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