Previous Preeclamptic Pregnancy and Chronic Hypertension Affects Current Preeclampsia at a Public Health Center in Bojonegoro, Indonesia [Accepted]
Abstract
Preeclampsia is a cause of maternal mortality which highly occurs in Indonesia. The high maternal mortality rate (MMR) reflects the low quality of health services during pregnancy, childbirth and the postpartum periodTo analyze the risk factors for the incidence of preeclampsia in pregnant women at Public Health Center, Sukosewu, Bojonegoro, Indonesia. Materials and Methods: The design of this study was a cross sectional. Samples involved in this study were 120 pregnant women at Public Health Center, Sukosewu, Bojonegoro District, Indonesia. The tests applied in this study were odds ratio and logistic regression tests. Results: The variables of gravida (p=0.046) and the history of chronic hypertension (p=0.015) had a positive significant (p <0.05) effect on the incidence of preeclampsia, while the variables of family history (p=0.079), twin pregnancy (p=0.999), gestational distance (p=0.261), age (p=0.132), BMI (p=0.336), MAP (p=0.997), history of hypertension in pregnancy (p=0.260), and history of DM (p=1.000) had no significant effect on the incidence of preeclampsia. Conclusion: The incidence of preeclampsia in pregnant women at Public Health Center, Sukosewu, Bojonegoro, Indonesia, was contributed by the risk factors of previous preeclampsia and a history of chronic hypertension in pregnancy.
Keywords: Risk factors of preeclampsia; gravida; chronic hypertension
References
Facca TA, Famá EAB, Mastroianni-Kirsztajn G, Sass N. “Why Is Preeclampsia still an Important Cause of Maternal Mortality Worldwide?” Rev Bras Ginecol Obstet. 2020 Sep;42(9):586-587. doi: 10.1055/s-0040-1714132
.
Chang KJ, Seow KM, Chen KH. “ Preeclampsia: Recent Advances in Predicting, Preventing, and Managing the Maternal and Fetal Life-Threatening Condition”. Int J Environ Res Public Health. 2023 Feb 8;20(4):2994. doi: 10.3390/ijerph20042994.
Akbar MIA, at all, 2018. “The Massive Problem of Preeclampsia in Indonesia : In need of a designed national health care system”. Science Direct Volime 13, supplement 1, October 2028 page 516. https://doi.org/10.1016/j.preghy/2018.08.051
Meazaw MW, Chojenta C, Muluneh MD, Loxton D. “Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa”. PLoS One. 2020 Aug 19;15(8):e0237600. doi: 10.1371/journal.pone.0237600.
Dinas Kesehatan Kabupaten Bojonegoro, “Profil Kesehatan Kabupaten Bojonegoro 2019”
Karrar SA, Martingano DJ, Hong PL. “Preeclampsia. Treasure Island (FL)”: StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/sites/books/NBK570611/
Turgut F, Awad AS, Abdel-Rahman EM. “Acute Kidney Injury: Medical Causes and Pathogenesis”. J Clin Med. 2023 Jan 3;12(1):375. doi: 10.3390/jcm12010375.
Krishnan S, Suarez-Martinez AD, Bagher P, Gonzalez A, Liu R, Murfee WL, Mohandas R. “Microvascular dysfunction and kidney disease: Challenges and opportunities? Microcirculation. 2021 Apr;28(3):e12661. doi: 10.1111/micc.12661.
Vlasopoulou K, Synetos A, Ktenopoulos N, Katsaros O, Koliastasis L, Apostolos A, Drakopoulou M, Toutouzas K, Tsioufis C. “Unmasking Left Ventricular Diastolic Dysfunction: Pathophysiology, Diagnosis, and Treatment Strategies”. Med Sci (Basel). 2025 Sep 22;13(3):204. doi: 10.3390/medsci13030204.
Fox R, Kitt J, Leeson P, Aye CYL, Lewandowski AJ. “Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring”. J Clin Med. 2019 Oct 4;8(10):1625. doi: 10.3390/jcm8101625.
Alipova G, Ablakimova N, Tussupkaliyeva K, Bermagambetova S, Kosmuratova S, Karimsakova B, Gaiday A, Gaiday A, Dinets A, Tussupkaliyev A. Prevention of Pre-Eclampsia: Modern Strategies and the Role of Early Screening”. J Clin Med. 2025 Apr 25;14(9):2970. doi: 10.3390/jcm14092970
Mustary M, Ansariadi, Syam A, Riskiyani S, Erika KA, Moedjiono AI, Lubis M.” Preeclampsia: Etiology, Pathophysiology, Risk Factors, Impact and Prevention: A Narrative Review”. Iran J Public Health. 2024 Nov;53(11):2392-2403. doi: 10.18502/ijph.v53i11.16941.
Saraswati Nuning, Mardiana, 2019 . “Faktor Risiko yang Berhubungan dengan Kejadian Preeklampsia pada Ibu Hamil ( Studi Kasus di RSUD Kab Brebes”, Journal.unnes.ac.id/sju/index.php/ujph, UJPH 5 (2)
K. Huma, Gul Sundas, Habib M, “Maternal Risk Factors and Outcome in Primigravida patient with Preeclampsia and eclampsia”, May 2025, Insight Journal of Health and Rehabilitation 3 : 472 – 477, doi : 10.71000/p5x9tr08.
Aziz, Maneeza1; Kokiwar, Prashant Ramdas2. “Effectiveness of Counseling in Reducing Pregnancy-related Anxiety among Primigravida Women – A Quasi-experimental Study”. Journal of Medical Sciences 45(5):p 183-188, Sep–Oct 2025. | DOI: 10.4103/jmedsci.jmedsci_32_25
Angsar, M.D, 2020. “Hipertensi dalam Kehamilan. Ilmu Kebidanan Sarwono Prawirohardjo”, Jakarta : PT Bina Pustaka Sarwono Prawirohardjo S
Repley JM, Bates K, Mohiuddin SS. “Physiology, Maternal Changes”. [Updated 2023 Mar 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539766/
Karima Nurulia M, Machmud Rizanda, Yusrawati, 2017. “Hubungan Faktor Risiko dengan Kejadian Preeklampsia Berat di RSUP Dr M. Djamil Padang”. Jurnal.fk.unand.ac id hal 556
S Njorage, M Kuriloff, A Mueller, J.L Perdigoo, R.Dhir, S.Rana. “The Interval between births and the risk of recurrent preeclampsia among predominantly high risk women in urban tertiary care center”. Pregnancy Hypertension vol 25, August 2021 pages 7-11. Doi : 10.1016/j.preghy.2021.05.009
Shimizu, H., Murakoshi, T., Wakisaka, S. et al. “Evaluating the risk factors for preeclampsia in subsequent pregnancies in patients with a history of preeclampsia: a single-institution retrospective study”. Hypertens Res 48, 1315–1320 (2025). https://doi.org/10.1038/s41440-025-02098-y
Flint B, Tadi P. “Physiology, Aging”. [Updated 2023 Jan 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK556106/
Cífková R. Hypertension in Pregnancy: A Diagnostic and Therapeutic Overview. High Blood Press Cardiovasc Prev. 2023 Jul;30(4):289-303. doi: 10.1007/s40292-023-00582-5. Epub 2023 Jun 13.
Nursal D.G.A, Tamela P, Fitrayeni, 2018. “Faktor Risiko Kejadian Preeklampsia pada Ibu Hamil di RSUP DR. M Djamil Padang” Jurnal Kesehatan Masyarakat Andalas p-ISSN 1978-2828
Lin X, Li H. “Obesity: Epidemiology, Pathophysiology, and Therapeutics”. Front Endocrinol (Lausanne). 2021 Sep 6;12:706978. doi: 10.3389/fendo.2021.706978.
Henning RJ. “Obesity and obesity-induced inflammatory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity”. Am J Cardiovasc Dis. 2021 Aug 15;11(4):504-529.
Stubert J, Reister F, Hartmann S, Janni W. “The Risks Associated With Obesity in Pregnancy”. Dtsch Arztebl Int. 2018 Apr 20;115(16):276-283. doi: 10.3238/arztebl.2018.0276.
Zhu J, Zhang J, Syaza Razali N, Chern B, Tan KH. “Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study”. BMJ Open. 2021 Aug 13;11(8):e046161. doi: 10.1136/bmjopen-2020-046161.
Syahriana, 2018, “Analisis Mean arterial Presure, Roll Over Test, Indeks Massa Tubuh, Low Density Lipoprotein, dan High Density Lipoprotein Sebagai Faktor Prediktor Hipertensi dalam Kehamilan”. Sekolah Pascasarjanan Universitas Hasanudin Makasar.
X Nie, Z Xui, H Ren, “Analysis of risk factors of preeclampsia in pregnancy women with chronic hypertension and its impact pregnancy outcomes”. BMC Pregnancy and childbirth 24, article no 307(2024) https://doi.org/10.1186/s12884-024-06476-1
Khedagi AM, Bello NA. “Hypertensive Disorders of Pregnancy”. Cardiol Clin. 2021 Feb;39(1):77-90. doi: 10.1016/j.ccl.2020.09.005. Epub 2020 Nov 2.
Ramanlal R, Gupta V. “Physiology, Vasodilation”. [Updated 2023 Jan 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/sites/books/NBK557562/
Do NC, Vestgaard M, Nørgaard SK, Damm P, Mathiesen ER, Ringholm L. “Prediction and prevention of preeclampsia in women with preexisting diabetes: the role of home blood pressure, physical activity, and aspirin.” Front Endocrinol (Lausanne). 2023 Aug 8;14:1166884. doi: 10.3389/fendo.2023.1166884.
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